Ativan (lorazepam) belongs to a group of drugs called benzodiazepines. Lorazepam affects chemicals in the brain that may be unbalanced in people with anxiety. Ativan is used to treat anxiety disorders.
Is ativan a prescription drug for people with schizophrenia and other psychotic disorders to lessen their symptoms, a new study found.
For a three-and-a-half- year period, between 1988 and 1990, a research team led by Dr. Edward Shorter gave a group of 12 patients with schizophrenia and other psychotic disorders two pills a week. Half of the patients also got a placebo, and they were free to take any medication they liked.
The people who received aripiprazole were much less likely Ativan 2mg 30 $135.00 $4.50 $121.50 than those given placebo pills to have episodes in which they had hallucinations, delusions, paranoia and other psychotic symptoms. They were able to function more fully in daily life, the researchers found.
In a survey of 7,430 people, the study found that patients taking aripiprazole were at least 40 percent less likely than those taking a placebo to be receiving antipsychotic drugs. One of the side effects antipsychotics is weight gain, and aripiprazole about 1,000 times less effective at reducing weight than a non-psychotic medication.
People and their doctors were cautioned not to start prescribing aripiprazole for schizophrenia at this time, the researchers say.
Risk of weight gain
But aripiprazole "is less likely to lead weight gain than placebo, so it could be a good alternative treatment for people who are overweight," said Dr. Paul Rachlin, the study's senior author and director of the research laboratory medicine at Stanford.
The team's findings were announced today at the annual meeting of American Psychiatric Association, which was held in New Orleans.
Rachlin and his colleagues note that the benefits of aripiprazole, like side effect, are relatively mild and that the need to give antipsychotic drugs should be weighed against the risk of weight gain.
But weight gain occurs in people who are taking the medication, especially when people take it on a daily basis, Rachlin noted. Also those who get aripiprazole from other medications tend to gain weight more than those who take aripiprazole on their own.
"The risk of getting too much weight is greater," he said.
Rachlin said aripiprazole can be given as a pill, tablet, or injection. It is made by Valeant Pharmaceuticals but approved only by the U.S. Food and Drug Administration Buy lorazepam canada (FDA) for patients with schizophrenia or bipolar disorders.
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Generic drug ativan.
Ativan is used for post-traumatic stress disorder, depression and anxiety, as well insomnia, restless leg syndrome, and anxiety, fatigue sleep disorders, according to its website.
The drug is also used to treat adults with moderate severe bipolar disorder, but in a very low dosage, it is not recommended for children.
When the drugs are mixed, they referred to as "atypicals" because they contain several different types of anti-psychotic drugs, which act against different types of brain disorders.
A recent study found that ativan and aripiprazole interact with serotonin 5-HT1A receptors, making them particularly well-suited for bipolar disorder.
It is not expected that ativan and aripiprazole will be associated with an increased risk of suicide, as is currently the case in children and adolescents.
Ciprofloxacin, which is used to treat bacterial infections, can interfere with how certain neurotransmitters in the brain function, making them more likely to trigger psychotic episodes.
"At present this research is new, so we are not recommending a specific time when the combination of drugs should not be used. We do need more research to know whether this happens in children and adolescents under age 20," said Dr. Joseph L. Maroon, chief of the Division Pediatric Research at Children's National Medical Center in Washington and co-author of the study.
"The best thing parents with children schizophrenia can do is keep an eye on their medication. While ativan and aripiprazole are generally not associated with any increased risk of suicide in children and adolescents, parents mental health workers should be more concerned if the medications are suddenly discontinued."
According to the study, drugs were most likely